| Autor: |
Saffian, SM, Duffull, SB, Wright, DFB |
| Předmět: |
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| Zdroj: |
Clinical Pharmacology & Therapeutics; Aug2017, Vol. 102 Issue 2, p297-304, 8p |
| Abstrakt: |
There is preliminary evidence to suggest that some published warfarin dosing algorithms produce biased maintenance dose predictions in patients who require higher than average doses. We conducted a meta-analysis of warfarin dosing algorithms to determine if there exists a systematic under- or overprediction of dose requirements for patients requiring ≥7 mg/day across published algorithms. Medline and Embase databases were searched up to September 2015. We quantified the proportion of over- and underpredicted doses in patients whose observed maintenance dose was ≥7 mg/day. The meta-analysis included 47 evaluations of 22 different warfarin dosing algorithms from 16 studies. The meta-analysis included data from 1,492 patients who required warfarin doses of ≥7 mg/day. All 22 algorithms were found to underpredict warfarin dosing requirements in patients who required ≥7 mg/day by an average of 2.3 mg/day with a pooled estimate of underpredicted doses of 92.3% (95% confidence interval 90.3-94.1, I2 = 24%). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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