| Autor: |
Yu, Hongchang, Zhu, Baowu, Zhan, Yulian |
| Předmět: |
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| Zdroj: |
Bioresources & Bioprocessing; 7/17/2017, Vol. 4 Issue 1, p1-4, 4p |
| Abstrakt: |
Background: Artemisinin ( 1) and its derivatives are now being widely used as antimalarial drugs, and they also exhibited good antitumor activities. So there has been much interest in the structural modification of artemisinin and its derivatives because of their effective bioactivities. The microbial transformation is a promising route to obtain artemisinin derivatives. The present study focuses on the microbial transformation of artemisinin by Aspergillus terreus. Results: During 6 days at 28 °C and 180 rpm, Aspergillus terreus transformed artemisinin to two products. They were identified as 1-deoxyartemisinin ( 2) and 4α-hydroxy-1-deoxyartemisinin ( 3) on the basis of their spectroscopic data. Conclusions: The microbial transformation of artemisinin by Aspergillus terreus was investigated, and two products (1-deoxyartemisinin and 4α-hydroxy-1-deoxyartemisinin) were obtained. This study is the first to report on the microbial transformation of artemisinin by Aspergillus terreus. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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