| Autor: |
Haller, Nils, Tug, Suzan, Breitbach, Sarah, Jörgensen, Arne, Simon, Perikles |
| Předmět: |
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| Zdroj: |
International Journal of Sports Physiology & Performance; Apr2017, Vol. 12 Issue 4, p455-462, 8p, 1 Diagram, 1 Chart, 3 Graphs |
| Abstrakt: |
Purpose: Increases in concentrations of circulating cell-free DNA (cfDNA) have recently been demonstrated to occur in a variety of exhausting and vigorous exercise settings. Here, the authors assessed the association of cfDNA with exercise duration and intensity in a controlled test-retest setting of a regenerative up-to-moderate-level aerobic run. Methods: In a pretest, the lactate threshold (LT) was determined in 13 participants (range 10.8-13.4 km/h) by using a step-wise incremental running test. The speed of the 2 endurance runs was set to 9.6 km/h for 40 min; for the participants with an LT below the median (12.8 km/h; Gl), this was a moderate aerobic run, and for those with an LT above the median, this was a regenerative run (G2). Capillary cfDNA, lactate, and rating of perceived exertion (RPE) were assessed before, every 10 min during, and after the runs. Results: During the last 30 min of the 2 runs, lactate did not increase, whereas cfDNA increased steadily (3.46-fold for Gl and 2.05- fold for G2). Intraclass correlation for cfDNA was high (r = .81, P < .0001) for all runners but higher for male participants (r = .92, P < .0001). The correlations of cfDNA and lactate with RPEs were r = .58 (P < .0001 ) and r = .32 (P < .05), respectively. Conclusions: Both duration and level cf intensity were significantly associated with accumulation of cfDNA. The correlation with RPE and the high test-retest reliability suggest that cfDNA might be applicable as a marker to monitor individual training load for aerobic and intermittent exercises. Future randomized, controlled, longitudinal training studies will have to reveal the full potential of cfDNA as an exercise-physiology marker. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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