Chemotherapy-induced neutropenia as a prognostic factor in patients with metastatic pancreatic cancer treated with gemcitabine.

Autor:	Otake, Aki, Tsuji, Daiki, Taku, Keisei, Kawasaki, Yohei, Yokoi, Mari, Nakamori, Harumi, Osada, Marika, Matsumoto, Megumi, Inoue, Kazuyuki, Hirai, Keita, Itoh, Kunihiko
Předmět:	THERAPEUTIC use of antimetabolites ANTIMETABOLITES C-reactive protein CONFIDENCE intervals METASTASIS MULTIVARIATE analysis NEUTROPENIA PANCREATIC tumors PROBABILITY theory RESEARCH STATISTICS SURVIVAL analysis (Biometry) MATHEMATICAL variables PROPORTIONAL hazards models RETROSPECTIVE studies LOG-rank test PROGNOSIS
Zdroj:	European Journal of Clinical Pharmacology; Aug2017, Vol. 73 Issue 8, p1033-1039, 7p
Abstrakt:	Purpose: Chemotherapy-induced neutropenia (CIN) is a common side effect of chemotherapy and an important dose-limiting factor. However, an association between CIN development and longer survival was recently reported in several solid cancers. In the present study, we aimed to assess whether CIN could be a prognostic factor and clarify other prognostic factors for patients with metastatic pancreatic cancer. Methods: We retrospectively analyzed the medical records of 84 patients who received gemcitabine monotherapy as first-line chemotherapy for metastatic pancreatic cancer to assess whether CIN could be a prognostic factor. Potential prognostic factors of survival were examined by univariate and multivariate analyses using the log-rank test and Cox proportional hazard model, respectively. Results: Median survival time was 170 days [95% confidence interval (CI), 147-193] in patients without CIN (grade 0), 301 days (95% CI, 152-450) in patients with grade 1-2 CIN, and 406 days (95% CI, 271-541) in patients with grade 3 CIN. The multivariate analysis revealed that a pretreatment C-reactive protein level of <0.50 mg/dL [hazard ratio (HR), 0.534; 95% CI, 0.323-0.758, P = 0.015] and grade 3 CIN (HR, 0.447; 95% CI, 0.228-0.875, P = 0.019) were independent favorable prognostic factors in patients with metastatic pancreatic cancer treated with gemcitabine. Conclusions: Neutropenia during chemotherapy was associated with increased survival of patients with metastatic pancreatic cancer. Monitoring of CIN could be used to predict treatment responsiveness. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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