| Autor: |
Chieregato, Arturo, Venditto, Alessandra, Russo, Emanuele, Martino, Costanza, Bini, Giovanni |
| Předmět: |
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| Zdroj: |
Acta Neurochirurgica; Aug2017, Vol. 159 Issue 8, p1553-1559, 7p, 1 Chart, 3 Graphs |
| Abstrakt: |
Background: The outcome of patients with severe traumatic brain injury (TBI) and acute traumatic subdural hematoma (aSDH) admitted to the emergency room with bilaterally dilated, unreactive pupils (bilateral mydriasis) is notoriously poor. Methods: Of 2074 TBI patients consecutively admitted to our facility between 1997 and 2012, 115 had a first CT scan with aSDH, unreactive bilateral mydriasis, and a Glasgow Coma Score of 3 or 4. Sixty-two patients were unoperated and died within hours or a few days. The remaining 53 patients (2.5% of the 2074 consecutive patients) were scheduled for emergent evacuation of the aSDH. We compared three different dosages of mannitol to landmark different comprehensive levels of treatment: (1) a ' basic' level of treatment characterized by a single conventional dose (18 to 36 g), (2) ' reinforced' treatment landmarked by a single high dose (54 to 72 g), and (3) ' aggressive' treatment landmarked by a single high dose (90 to 106 g). Doses above 36 g were administered intravenously over a period of 5 min. Results: Of the 53 selected patients, 7 were aggressively managed (13.2%) and 24 (45.3%) received reinforced treatment. Rates of hyperventilation and barbiturate bolus administration were appropriately associated with increasing doses of mannitol. After adjustment for age, aggressive management was significantly associated with a lower risk of death and persistent vegetative state [adjusted OR 0.016 (95% 0.001-0.405)]. Patients surviving after aggressive management suffered more severe disability at 1 year. Conclusion: The study shows an association between reduced mortality and persistent vegetative state, albeit at the cost of increased long-term severe disability in survivors, and aggressive medical preoperative management of mydriatic patients with aSDH following TBI. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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