| Autor: |
Teixeira Silva, Carla, Cândido, ana Paula Carlos, Pala, Daniela, Oliveira Barbosa, Priscila, Machado-Coelho, George Luiz Lins, Pereira de Oliveira, Fernando Luiz, Pinheiro Volp, ana Carolina, Nascimento de Freitas, Renata |
| Předmět: |
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| Zdroj: |
Annals of Nutrition & Metabolism; Jul2017, Vol. 70 Issue 4, p259-267, 9p, 4 Charts |
| Abstrakt: |
Background: Clusters of cardiovascular risk (CVR) factors are associated with an increased risk of developing cardiovascular diseases (CVDs). This cross-sectional study assessed the associations between classic CVR factor clusters and inflammatory markers in Brazilian adolescents. Methods: Measurements included anthropometric, clinical and biochemical parameters and selected inflammatory markers in 487 adolescents (236 boys/251 girls; 12.06 ± 1.41 years). Results: After stratifying the population by gender and adjusting for potential confounding variables, principal component analysis was performed and it produced 5 independent components in both genders: adiposity, glucose metabolism, blood pressure, high-density lipoprotein (HDL)/triacylglycerols (TG), and cholesterol/low-density lipoprotein. Glucose metabolism was inversely associated with interleukin-1β (IL-1β) in both genders ( r = –0.026; r = –0.021); blood pressure was inversely associated with tumor necrosis factor alpha (TNF-α) in girls ( r = –0.046); HDL/TG was positively associated with interleukin-6 in girls ( r = 0.012), with IL-1β ( r = 0.010) TNF-α ( r = 0.045) in boys, and inversely associated with adiponectin in both genders ( r = –0.015; r = –0.013). Conclusion: The results suggest that lipid metabolism alterations, as potential early events in the development of CVDs, have a strong link to the inflammatory process, in contrast to other clusters of risk factors. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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