| Autor: |
Chagas, Pietro M., Fulco, Bruna C.W., Sari, Marcel H.M., Roehrs, Juliano A., Nogueira, Cristina W. |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacy & Pharmacology; Aug2017, Vol. 69 Issue 8, p1022-1032, 11p |
| Abstrakt: |
Bis(phenylimidazoselenazolyl) diselenide ( BPIS) is an organoselenium with acute antinociceptive and antioxidant properties. Objectives The aim of this study was to investigate BPIS effect on a collagen-induced arthritis ( CIA) model in mice. Methods Protocol of exposure consisted in arthritis induction by chicken collagen type II on day 0 with booster injection on day 21. On day 60 after collagen injection, incidence of mechanic allodynia (Von Frey test) or thermal hyperalgesia (hot plate test) was evaluated. During following 5 days, mice were treated with BPIS (0.1-1 mg/kg; p.o.; daily) or vehicle. On day 65, mice were killed, and paws and spinal cord were removed for analyses. Key findings Mice submitted to CIA model developed both mechanical allodynia and thermal hyperalgesia, which were reversed by BPIS at the highest dose. In paw, BPIS reversed the increase in myeloperoxidase activity in the CIA group. In the spinal cord, BPIS decreased NOx and NFkB levels increased in the CIA group. BPIS-treated animals had lower cyclooxygenase-2 levels in the spinal cord. Conclusions The myeloperoxidase activity in paw and NOx and NFkB levels in spinal cord are related to antinociceptive properties of BPIS in CIA model. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text