| Autor: |
Saletu, B., Darragh, A., Breuel, H. P., Herrmann, W., Salmon, P., Coen, R., Anderer, P. |
| Předmět: |
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| Zdroj: |
Human Psychopharmacology: Clinical & Experimental; Dec91, Vol. 6 Issue 4, p267-275, 9p |
| Abstrakt: |
In a double-blind, placebo-controlled parallel group study, the encephalatropic effects of multiple doses of linopirine (I)VP P16), a novel phenylindolinone derivative enhancing the stimulated release of acetylcholine in cholinergic nerve terminals, hut also increasing concentrations of dopamine and serotonin, were investigated in 30 elderly. healthy volunteers. Fifteen subjects were randomly assigned to receive 20 mg DUP 996 b.i.d. and 15 were assigned It' receive placebo The doses were given at 12-h intervals for 10 days with an additional morning dose on day II Multi-lead LEG recordings were obtained alter an adaptation session on day - 1. as well as on days 2, 5 and 1(1 prior to and in the second hour after the morning dose. Computer-assisted spectral analysis of the EEC and subsequent topographic brain mapping of the drug-induced EEC changes demonstrated significant central effects of DUP 996,characterized h) art augmentation of total power, decrease of delta and theta activity, increase in alpha and beta activity and an acceleration of the centroid. These findings are opposite to those seen in dementias and indicative of an improvement in vigilance, and lime also been described with other cognition-enhancing drugs. Time-course investigations demonstrated more CNS changes 2 hours after than before morning oral dosing on days 2 and 5. The pharmacodynamic peak was observed in the 2 hour after dosing on day 2, topographically, the drug-induced changes over time were most pronounced over frontal-temporal. temporal-occipital, parietal and frontal regions. e.g. over brain areas afflicted most by Alzheimer's disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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