Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica.

Autor: Fumitaka Shimizu, Schaller, Kristin L., Owens, Gregory P., Cotleur, Anne C., Kellner, Debra, Yukio Takeshita, Obermeier, Birgit, Kryzer, Thomas J., Yasuteru Sano, Takashi Kanda, Lennon, Vanda A., Ransohoff, Richard M., Bennett, Jeffrey L.
Předmět:
Zdroj: Science Translational Medicine; 7/5/2017, p1-12, 12p
Abstrakt: The article discusses a propose study on the use of endothelial cell–targeted autoantibody as treatment for neuromyelitis optica (NMO), an inflammatory disorder. The study examines the use of monoclonal recombinant antibodies from patients with NMO and its enhanced transit of macromolecules. The study also suggests the possibility of glucose-regulated protein 78 (GRP78) as antibodies.
Databáze: Complementary Index