| Autor: |
E. Wickstrøm, Leo E., Godtlibsen, O. B., Bredesen, J. E., Jensen, M. H. |
| Předmět: |
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| Zdroj: |
Human Psychopharmacology: Clinical & Experimental; Mar88, Vol. 3 Issue 1, p3-11, 9p |
| Abstrakt: |
The effects of zopiclone 7-5 and 15 mg triazolam 0-25 and 0-5 mg, flunitrazepam 1 and 2mg, ethanol and placebo on performance, mood and sleep onset latency after partial sleep deprivation, were compared in a randomized, double-blind, crossover, single-dose study. Sixteen healthy volunteers of both sexes, aged 21-31 years. were included in the study. The overall assessment of the total psychological measurement indicated that zopiclone 7-5 mg, triazolam 0-25 mg and ethanol (C max=0-40 parts per thousand) did not affect the daytime performance of an unacceptable degree even when given late at night. The findings for flunitrazepam I mg were not so uniform, but also seemed acceptable. Zopiclone 15mg, triazolam 0-5mg and flunitrazepam 2mg were rated as not acceptable alternatives. No significant differences were shown concerning mood. The overall assessment for sleep onset latency and subjective aleterness indicated that zopiclone 7-5mg and triazolam 0-25mg had a more appropriate profile than the other drugs and doses rested. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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