| Autor: |
Kao, Chai‐Lin, Huang, Adela Ya‐Ting, Chen, Hui‐Ting |
| Předmět: |
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| Zdroj: |
Macromolecular Rapid Communications; Jun2017, Vol. 38 Issue 12, pn/a-N.PAG, 6p |
| Abstrakt: |
Here, this study overcomes the current barriers to efficient solid-phase synthesis of high-generation dendrimers by decreasing the loading ratio on the resin. G7 inverse poly(amidoamine) dendrimer is now prepared, for the first time, through a solid-phase synthesis using only 50% of the available reactive sites and by choosing a large resin. This preparation takes only 15 d to afford highly pure product in 80% yield with precipitation being the only purification procedure used. The results clearly show the amount of the initial monomer loaded on the resin to be a vital factor for the ability to use solid-phase synthesis to produce large dendrimers. This finding also sets stage for the applications of solid-phase synthesis for the preparation of other macromolecules. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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