| Autor: |
Dahlke, Christine, Lunemann, Sebastian, Kasonta, Rahel, Kreuels, Benno, Schmiedel, Stefan, Ly, My L., Fehling, Sarah K., Strecker, Thomas, Becker, Stephan, Altfeld, Marcus, Sow, Abdourahmane, Lohse, Ansgar W., Muñoz-Fontela, César, Addo, Marylyn M. |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 1/15/2017, Vol. 215 Issue 2, p287-292, 6p |
| Abstrakt: |
The West African Ebola virus disease (EVD) outbreak was the largest EVD outbreak in history. However, data on lymphocyte dynamics and the antigen specificity of T cells in Ebola survivors are scarce, and our understanding of EVD pathophysiology is limited. A case of EVD survival in which the patient cleared Ebola virus (EBOV) infection without experimental drugs allowed for the detailed examination of lymphocyte dynamics. We demonstrate the persistence of T-cell activation well beyond viral clearance and detect EBOV-specific T cells. Our study provides significant insights into lymphocyte specificity during the recovery phase of EVD and may inform novel strategies to treat EVD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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