Effects of Combined Transplantation of Multipotent Mesenchymal Stromal and Hemopoietic Stem Cells on Regeneration of the Hemopoietic Tissue.

Autor:	Maklakova, I., Grebnev, D.
Předmět:	HEMATOPOIETIC system STEM cells STEM cell transplantation REGENERATION (Biology) IMMUNOSUPPRESSION
Zdroj:	Bulletin of Experimental Biology & Medicine; May2017, Vol. 163 Issue 1, p61-64, 4p
Abstrakt:	The effect of allogenic combined transplantation of placental multipotent mesenchymal stromal and hemopoietic stem cells on regeneration of the myeloid tissue and spleen after acute blood loss was studied in laboratory mice. Combined transplantation of these cells did not change the content of cytogenetically modified cells in the bone marrow under normal conditions, but reduced their levels after acute blood loss. Combined transplantation of multipotent mesenchymal stromal and hemopoietic stem cells promoted activation of erythropoiesis and granulocytopoiesis. The major morphometric and cytological parameters of the white pulp of the spleen decreased, presumably due to immunosuppressive effect of multipotent mesenchymal stromal cells. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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