| Autor: |
Thenge, Raju Rameshrao, Patond, V. B., Adhao, Vaibhav Suresh, Ajmire, Prashant Vishnupant, Barde, Laxmikat Niranjan, Mahajan, Nilesh M., Tekade, Nilesh P. |
| Předmět: |
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| Zdroj: |
Indonesian Journal of Pharmacy / Majalah Farmasi Indonesia; 2017, Vol. 28 Issue 1, p34-41, 8p |
| Abstrakt: |
Diacerein, an anti-inflammatory drug used in the treatment of osteoarthritis. Being a BCS class II drug, it has poor solubility, dissolution rate, and other physicochemical properties. Thus the aim of present study was to prepare co-crystals of diacerein to improve solubility and dissolution rate. The diacerein co-crystals were prepared using urea and tartaric acid as conformer by Solvent drop grinding method. The diacerein cocrystals were characterized by scanning electron microscopy (SEM), Fourier Transform Infrared Spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and X-ray diffractometry (XRD). The co-crystals were evaluated for solubility, dissolution rate, and other physicochemical properties and compared with commercial diacerein. The co-crystals exhibit the difference in the size and shape of crystals. The FT-IR spectra of diacerein cocrystals showed slightly different in the characteristic peaks compared to commercial diacerein sample. DSC data indicate the decrease in the melting endotherm of co-crystals compares to diacerein. The co-crystals with urea showed an increase and intense peak and co-crystals with tartaric acid showed decreased number of peaks compared to commercial diacerein. The cocrystals of diacerein formulated into the Tablet and evaluated for tablet properties. The tablet formulation showed improved tablet characteristics as well as dissolution rate compared to commercial diacerein. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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