| Autor: |
Nagaraju, Dharavath, Rajanarendar, Eligeti, Praveen Kumar, Pittala, Nagi Reddy, Modugu |
| Předmět: |
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| Zdroj: |
New Journal of Chemistry; 6/21/2017, Vol. 41 Issue 12, p4783-4787, 5p |
| Abstrakt: |
An efficient and green approach for the sp3 C–H bond functionalization of 2-methyl azaarenes to 3-methyl-4-nitro-5-styrylisoxazoles in water has been described. Nitrostyrylisoxazoles were proven to be good C=C electrophilic acceptors for the construction of various azaarene-containing Michael addition products. This method provides an efficient and environmentally benign method for the one-pot synthesis of biologically important azaarene-substituted isoxazole derivatives in good yields. The important aspects of the present methodology are the use of non-toxic solvent, that it is catalyst free, the ease of purification and the large substrate scope. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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