Assessment of regional emphysema, air-trapping and Xenon-ventilation using dual-energy computed tomography in chronic obstructive pulmonary disease patients.

Autor:	Lee, Sang, Seo, Joon, Hwang, Hye, Kim, Namkug, Oh, Sang, Lee, Jae, Lee, Sei, Oh, Yeon-Mok, Kim, Tae, Lee, Sang Min, Seo, Joon Beom, Hwang, Hye Jeon, Oh, Sang Young, Lee, Jae Seung, Lee, Sei Won, Kim, Tae Hoon
Předmět:	OBSTRUCTIVE lung disease treatment PULMONARY emphysema treatment COMPUTED tomography XENON ARTIFICIAL respiration PULMONARY function tests THERAPEUTICS OBSTRUCTIVE lung disease diagnosis AIR COMPARATIVE studies DIAGNOSTIC imaging PULMONARY emphysema GASES LONGITUDINAL method LUNGS OBSTRUCTIVE lung diseases RESEARCH methodology MEDICAL cooperation RESEARCH RESPIRATION RESPIRATORY measurements EVALUATION research INHALATION administration INHALATION anesthetics DISEASE complications DIAGNOSIS
Zdroj:	European Radiology; Jul2017, Vol. 27 Issue 7, p2818-2827, 10p, 2 Color Photographs, 2 Diagrams, 7 Charts, 1 Graph
Abstrakt:	Objectives: To compare the parenchymal attenuation change between inspiration/expiration CTs with dynamic ventilation change between xenon wash-in (WI) inspiration and wash-out (WO) expiration CTs.Methods: 52 prospectively enrolled COPD patients underwent xenon ventilation dual-energy CT during WI and WO periods and pulmonary function tests (PFTs). The parenchymal attenuation parameters (emphysema index (EI), gas-trapping index (GTI) and air-trapping index (ATI)) and xenon ventilation parameters (xenon in WI (Xe-WI), xenon in WO (Xe-WO) and xenon dynamic (Xe-Dyna)) of whole lung and three divided areas (emphysema, hyperinflation and normal) were calculated on virtual non-contrast images and ventilation images. Pearson correlation, linear regression analysis and one-way ANOVA were performed.Results: EI, GTI and ATI showed a significant correlation with Xe-WI, Xe-WO and Xe-Dyna (EI R = -.744, -.562, -.737; GTI R = -.621, -.442, -.629; ATI R = -.600, -.421, -.610, respectively, p < 0.01). All CT parameters showed significant correlation with PFTs except forced vital capacity (FVC). There was a significant difference in GTI, ATI and Xe-Dyna in each lung area (p < 0.01).Conclusions: The parenchymal attenuation change between inspiration/expiration CTs and xenon dynamic change between xenon WI- and WO-CTs correlate significantly. There are alterations in the dynamics of xenon ventilation between areas of emphysema.Key Points: • The xenon ventilation change correlates with the parenchymal attenuation change. • The xenon ventilation change shows the difference between three lung areas. • The combination of attenuation and xenon can predict more accurate PFTs. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink