| Autor: |
Raunio, Anna, Myllykangas, Liisa, Kero, Mia, Polvikoski, Tuomo, Paetau, Anders, Oinas, Minna |
| Předmět: |
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| Zdroj: |
Journal of Alzheimer's Disease; 2017, Vol. 58 Issue 3, p669-674, 6p |
| Abstrakt: |
We investigated the frequency of Lewy-related pathology (LRP) in the amygdala among the population-based Vantaa 85+ study. Data of amygdala samples (N = 304) immunostained with two α-synuclein antibodies (clone 42 and clone 5G4) was compared with the previously analyzed LRP and AD pathologies from other brain regions. The amygdala LRP was present in one third (33%) of subjects. Only 5% of pure AD subjects, but 85% of pure DLB subjects had LRP in the amygdala. The amygdala LRP was associated with dementia; however, the association was dependent on LRP on other brain regions, and thus was not an independent risk factor. The amygdala-predominant category was a rare (4%) and heterogeneous group. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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