| Autor: |
Flange, Niklas, Kaup, Marion, Weber, Anke, Remky, Andreas, Arend, Oliver |
| Předmět: |
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| Zdroj: |
Archives of Ophthalmology; Feb2004, Vol. 122 Issue 2, p195-201, 7p |
| Abstrakt: |
Objectives: To evaluate absolute filling defects of the optic nerve head in normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG) and to compare the filling defects with topographic analysis of the optic disc. Methods: Twenty-five patients with NTG, 25 patients with POAG, and 25 age-matched controls were included. Fluorescein angiograms were performed by means of a scanning laser ophthalmoscope. The extent of absolute filling defects of the optic nerve head was assessed using digital image analysis of early-phase angiograms. Topographic measurements of the optic disc were acquired using the Heidelberg Retina Tomograph II. Results: Absolute filling defects were significantly larger (P = .001) and were seen more often (P<.001) in patients with NTG (n = 18) and POAG (n = 19) compared with controls (n = 3). Rim area (P = .006), rim volume (P = .007), cup-disc area ratio (P = .008), linear cup-disc ratio (P = .005), maximum cup depth (P = .002), cup shape measure (P = .03), and nerve fiber layer thickness (P = .008) and cross-sectional area (P = .006) were significantly different between patients with glaucoma and controls. Absolute filling defects were significantly correlated with cup area (r = 0.31; P = .007), rim area (r = -0.38; P<.001), rim volume (r = -0.35; P = .002), cup-disc area ratio (r = 0.49; P<.001), linear cup-disc ratio (r = 0.48; P<.001), cup shape measure (r = 0.27; P = .02), and nerve fiber layer thickness (r = -0.33; P = .004) and cross-sectional area (r = -0.30; P = .009). Conclusions: Fluorescein filling defects of the optic disc are present in NTG and POAG. The extent of these filling defects is correlated with the morphologic disc damage. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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