| Autor: |
Dou, Yuya, Zhang, Xiaodan, Li, Yang, Wang, Fenfen, Xie, Xing, Wang, Xinyu |
| Zdroj: |
Frontiers of Medicine; Jun2017, Vol. 11 Issue 2, p223-228, 6p |
| Abstrakt: |
The objective of this study is to guide a triage for the management of cervical high-grade squamous intraepithelial lesion (HSIL) patients with positive margin by conization. Clinico-pathological data of HSIL patients with positive margin by conization were retrospectively collected from January 2009 to December 2014. All patients underwent secondary conization or hysterectomy within 6 months. The rate of residual lesion was calculated, and the factors associated with residual lesion were analyzed by univariate and multivariate analyses. Among a total of 119 patients, 56 (47.06%) patients presented residual HSIL in their subsequent surgical specimens, including 4 cases of invasive cervical carcinoma (3 stage IA1 and 1 stage IA2 patients). Univariate analysis showed that patient age > 35 years ( P = 0.005), menopausal period > 5 years (P = 0.0035), and multiple-quadrant involvement ( P = 0.001) were significantly correlated with residual disease; however, multivariate analysis revealed that multiple-quadrant involvement ( P = 0.001; OR, 3.701; 95%CI, 1.496-9.154) was an independent risk factor for residual disease. Nearly half of HSIL patients with positive margin by conization were disease-free in subsequent surgical specimens, and those with multiple positive margins may consider reconization or re-assessment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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