| Abstrakt: |
[Trial design] A randomized, double-blind, placebo-controlled, parallel-group study was conducted to evaluate the effect of a tablet containing Pueraria flower extract (PFE) on visceral fat and liver function. [Method] One hundred thirty subjects with normal liver function whose body mass indexes (BMIs) were between 23 and < 30 were enrolled. The subjects were randomly divided into two groups and ingested either a test food containing PFE or a placebo for 12 weeks. Visceral fat area on computed tomography (CT) and liver function enzyme levels (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and γ-glutamyl transpeptidase [γ-GTP]), secondary end points, or safety evaluation items were measured before and at 4 (except for CT scan), 8, and 12 weeks after ingestion. [Results] Compared with the placebo, the test food significantly decreased the visceral fat area, body weight, BMI, waist circumference, hip circumference, subcutaneous fat area, and total fat area. As for the AST, ALT, γ-GTP levels, no significant differences were observed. During the study period, no abnormal changes attributable to the test food were observed. [Conclusion] These results indicate that the tablet containing PFE had an anti-obesity effect, but not an improvement effect, on liver function in subjects with normal liver function. [ABSTRACT FROM AUTHOR] |
