Three-Component One-Pot Reactions of 2-Trifluoromethyl-N-nosylaziridine, Primary Amines, and Vinylsulfonium Salts for Convenient Access to CF3-Containing Piperazines.

Autor:	Kensuke Hirotaki, Akiko Irie, Yuki Nakamura, Takeshi Hanamoto
Předmět:	FLUOROHYDROCARBONS AMINES SULFONIUM compounds CHEMICAL reactions PIPERAZINE RING formation (Chemistry)
Zdroj:	Synthesis; 2017, Vol. 49 Issue 11, p2488-2494, 7p
Abstrakt:	Trifluoromethylated piperazines were readily synthesized with excellent regioselectivity in high yields by the sequential reaction of 2-trifluoromethylated N-nosylaziridine (2-CF3-N-Ns-aziridine) with various primary amines, followed by treatment with vinylsulfonium salts, in one pot. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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