| Autor: |
Lakunina, V., Petrushanko, I., Burnysheva, K., Mitkevich, V., Makarov, A. |
| Předmět: |
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| Zdroj: |
Doklady Biochemistry & Biophysics; Mar2017, Vol. 473 Issue 1, p114-117, 4p |
| Abstrakt: |
We have shown that the inhibition of Na,K-ATPase during its long-term incubation with amyloid beta (Aβ), an Alzheimer's disease protein, is caused by the change in the thiol redox status of cells leading to induction of glutathionylation α-subunit of Na,K-ATPase. To restore the activity of Na,K-ATPase, it is proposed to use reducing agents, which promote normalization of the redox status of cells and deglutathionylation of the protein. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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