| Autor: |
Padilha Marchetti, Desirèe, Donida, Bruna, Deon, Marion, Eduardo Jacques, Carlos, Bannach Jardim, Laura, Regla Vargas, Carmen |
| Předmět: |
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| Zdroj: |
Clinical & Biomedical Research; 2017, Vol. 37 Issue 1, p33-37, 5p |
| Abstrakt: |
Introduction: Recent evidence shows that oxidative stress seems to be related with the pathophysiology of X-linked adrenoleukodystrophy (X-ALD), a neurodegenerative disorder. Methods: In the present study, the in vitro effect of N-acetyl-L-cysteine (NAC) on glutathione (GSH) and sulfhydryl levels in X-ALD patients was evaluated. Results: A significant reduction of GSH and sulfhydryl content was observed in X-ALD patients compared to the control group. Furthermore, 5 mM of NAC, in vitro, led to an increase in GSH content and sulfhydryl groups in these patients. Conclusion: These data probably indicate that an adjuvant therapy with the antioxidant NAC could improve the oxidative imbalance in X-ALD patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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