Investigation of the genetic overlap between rheumatoid arthritis and psoriatic arthritis in a Greek population.

Autor:	Myrthianou, E, Zervou, MI, Budu-Aggrey, A, Eliopoulos, E, Kardassis, D, Boumpas, DT, Kougkas, N, Barton, A, Sidiropoulos, P, Goulielmos, GN
Předmět:	RHEUMATOID arthritis treatment PSORIATIC arthritis GENOTYPES ALLELES HAPLOTYPES THERAPEUTICS ANTIGENS CARRIER proteins CYTOKINES DISEASE susceptibility ESTERASES GENETIC polymorphisms GENETIC techniques LONGITUDINAL method MATHEMATICAL models PROTEINS RHEUMATOID arthritis TRANSFERASES WHITE people THEORY CASE-control method SIGNAL peptides
Zdroj:	Scandinavian Journal of Rheumatology; May2017, Vol. 46 Issue 3, p180-186, 7p, 1 Diagram, 3 Charts
Abstrakt:	Objectives: Several rheumatoid arthritis (RA) susceptibility loci have also been found to be associated with psoriatic arthritis (PsA), demonstrating that there is a degree of genetic overlap between various autoimmune diseases. We sought to investigate whether single nucleotide polymorphisms (SNPs) mapping to previously reported RA and/or PsA susceptibility loci, including PLCL2, CCL21, REL, STAT4, CD226, PTPN22, and TYK2, are associated with risk for the two diseases in a genetically homogeneous Greek population.Method: This study included 392 RA patients, 126 PsA patients, and 521 healthy age- and sex-matched controls from Greece. Genotyping of the SNPs was performed with Taqman primer/probe sets. Bioinformatic analysis was performed using BlastP, PyMOL, and Maestro and Desmond.Results: A significant association was detected between the GC genotype of rs34536443 (TYK2) in both the PsA and RA cohorts. The C allele of this SNP was associated with PsA only. Evidence for association with PsA was also found for the GG genotype and G allele of the rs10181656 SNP of STAT4. The TC genotype of the rs763361 SNP of CD226 was associated with PsA only.Conclusions: Genetic overlap between PsA and RA was detected for the rs34536443 SNP of the TYK2 gene within a Greek population. An association of STAT4 (rs10181656) with PsA was confirmed whereas CD226 (rs763361) was associated with PsA but not with RA, in contrast to previous reports. The different findings of this study compared to previous ones highlights the importance of comparative studies that include various ethnic or racial populations. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.