A study of the impacts of low-intensity light irradiation in the red (λ = 635 nm) and green (λ = 520 nm) ranges on the proliferative activity and gene expression profiles of MNNG/hos cells and human fetal fibroblasts.

Autor: Ermakov, A., Chernov, A., Poltavtseva, R., Selezneva, I.
Zdroj: Biophysics; Jan2017, Vol. 62 Issue 1, p63-67, 5p
Abstrakt: It has been shown that a single low-intensity (0.146 mW/cm) irradiation of a cell culture of human fetal fibroblasts by a red LED (λ = 635 nm) at a dose of 175.2 mJ/cm led to a slight stimulation of culture growth, whereas light irradiation by a green LED (λ = 520 nm) at the same dose did not alter the proliferative activity of cultured fibroblasts. The growth of transformed MNNG/hos cells did not change at the selected irradiation modes. Both types of irradiation changed the expression profile of the proliferation and osteogenic differentiation genes of the fibroblast culture. In the transformed MNNG/hos cells, the red light promoted the expression of stemness genes, osteogenic differentiation genes, and cell-death markers. The transcription activity of cell-death markers and checkpoints in the MNNG/hos cells increased under the influence of the green light. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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