| Autor: |
Gajendrareddy, P. K., Junges, R., Cygan, G., Zhao, Y., Marucha, P. T., Engeland, C. G. |
| Předmět: |
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| Zdroj: |
Journal of Periodontal Research; Jun2017, Vol. 52 Issue 3, p644-649, 6p, 1 Color Photograph, 1 Graph |
| Abstrakt: |
Background and Objective The aim of this study was to evaluate the effects of increased oxygen availability on gene expression and on collagen deposition/maturation in the periodontium following disease. Material and Methods Male Wistar rats had ligatures placed around their molars to induce periodontal disease, and a subset of animals underwent hyperbaric oxygen ( HBO) treatment for 2 h twice per day. At 15 and 28 d, tissue gene expression of COL1A1, transforming growth factor-β1 and alkaline phosphatase was determined; other histological samples were stained with Picrosirius red to evaluate levels of collagen deposition, maturation and thickness. Results In animals that underwent HBO treatment, type I collagen expression was higher and collagen deposition, maturation and thickness were more robust. Reduced mRNA levels of transforming growth factor-beta1 and alkaline phosphatase in HBO-treated rats on day 28 suggested that a quicker resolution in both soft tissue and bone remodeling occurred following oxygen treatment. No differences in inflammation were observed between groups. Conclusions The extracellular matrix regenerated more quickly in the HBO-treated group as evidenced by higher collagen expression, deposition and maturation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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