| Autor: |
Cuende, Julia, Liénart, Stéphanie, Dedobbeleer, Olivier, van der Woning, Bas, De Boeck, Gitte, Stockis, Julie, Huygens, Caroline, Colau, Didier, Somja, Joan, Delvenne, Philippe, Hannon, Muriel, Baron, Frédéric, Dumoutier, Laure, Renauld, Jean-Christophe, De Haard, Hans, Saunders, Michael, Coulie, Pierre G., Lucas, Sophie |
| Předmět: |
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| Zdroj: |
Science Translational Medicine; 4/22/2015, Vol. 7 Issue 284, p1-12, 12p, 1 Diagram, 1 Chart, 4 Graphs |
| Abstrakt: |
The article focuses on findings of a study on effects of monoclonal antibodies against GARP/TGF-beta 1 complexes in inhibiting the immunosuppressive activity of human regulatory T cells. It states that two anti-GARP monoclonal antibodies were generated that block the production of the active TGF complexes, and mentions that antibodies recognizing other GARP epitopes did not block active TGF. It infers that blocking anti-GARP antibodies may improve the efficiency of cancer immunotherapy. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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