| Autor: |
Holobotovskyy, Vasyl, Yee Seng Chong, Burchell, Jennifer, He, Bo, Phillips, Michael, Leader, Leo, Murphy, Timothy V., Sandow, Shaun L., McKitrick, Douglas J., Charles, Adrian K., Tare, Marianne, Arnolda, Leonard F., Ganss, Ruth |
| Předmět: |
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| Zdroj: |
Science Translational Medicine; 6/3/2015, Vol. 7 Issue 290, p1-11, 11p, 1 Chart, 6 Graphs |
| Abstrakt: |
The article focuses findings of a study on role of regulator of G protein signaling 5 as a determinant of gestational hypertension and preeclampsia. It states that pregnant RGS5-deficient mice, reduced vascular RGS5 expression causes gestational hypertension by enhancing vascular sensitivity, and mentions that in heterozygote null mice, treatment with peroxisome proliferator–activated receptor agonists normalizes vascular function. It infers opportunity for treatment of the diseases. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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