Brain tuberculoma, an unusual cause of stroke in a child with trisomy 21: a case report.

Autor:	Kheir, Abdelmoneim E. M., Ibrahim, Salah A., Hamed, Ahlam A., Yousif, Badreldin M., Hamid, Farouk A.
Předmět:	TUBERCULOSIS in children DIAGNOSIS of tuberculosis in children BRAIN diseases DOWN syndrome PUBLIC health in developing countries STROKE risk factors TUBERCULOSIS treatment CARBAMAZEPINE STROKE HUMAN research subjects DEXAMETHASONE ANTI-inflammatory agents DIFFERENTIAL diagnosis TREATMENT effectiveness ANTITUBERCULAR agents DISEASE complications
Zdroj:	Journal of Medical Case Reports; 4/18/2017, Vol. 11, p1-4, 4p
Abstrakt:	Background: Tuberculosis remains a public health problem in developing countries and is associated with lethal central nervous system complications. Intracranial tuberculomas occur in 13% of children with neurotuberculosis. Patients with trisomy 21 have an increased risk for stroke, which usually stems from cardiovascular defects.Case Presentation: We report a case of a 12-year-old Sudanese boy with trisomy 21 who was presented to our hospital with focal convulsions and right-sided weakness. The results of neuroimaging and histopathological examinations were consistent with cerebral tuberculoma. The patient had a good initial response to antituberculosis drugs and steroids. To the best of our knowledge, this is the first case report of multiple brain tuberculomas described in a child with trisomy 21.Conclusions: Patients with trisomy 21 have an increased risk for stroke. Our patient had an exceptional case of stroke caused by tuberculoma. The present case emphasizes the need to consider tuberculomas in the differential diagnosis of children with neurological symptoms living in areas of high tuberculosis incidence. [ABSTRACT FROM AUTHOR]
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