| Autor: |
Shydlovska, Olga, Zholobak, Nadiya, Dybkova, Svitlana, Osinsky, Sergej, Bubnovskaya, Larissa, Yelenich, Oleksandr, Solopan, Sergii, Belous, Anatolii |
| Předmět: |
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| Zdroj: |
European Journal of Nanomedicine; Jan2017, Vol. 9 Issue 1, p33-43, 11p |
| Abstrakt: |
In the last decade, ferromagnetic nanoparticles that are able to be heated under an AMF (alternating magnetic field) have gained considerable interest in the field of nanotechnology. The current study explores the peculiarity of the synthesis and the properties of Fe3O4 and (La, Sr)MnO3 nanoparticles by cryochemical and sol-gel technology, as well the comparative analysis of biological activities of synthesized nanoparticles on different cell lines: the ST cell line (diploid epithelial swine testicular cell line) and the MCF-7S cell line (human breast cancer line). In the study, Fe3O4 and (La, Sr)MnO3 nanoparticles with superparamagnetic properties were synthesized, and magnetic fluids based on them that were efficiently heated when subjected to an AMF (specific loss power ~ 33-37 W/g) were prepared. It was observed that the temperature of magnetic fluids based on Fe3O4 nanoparticles increases linearly to the time of the AMF exposition, whereas for (La, Sr)MnO3-based fluid, it stabilizes within a given temperature range. It was shown that the nanoparticles of (La, Sr)MnO3, unlike Fe3O4, are characterized by low toxicity, antioxidant activity and the ability to influence on cell-virus interaction on normal cell lines (ST cell line). The possibility of the magnetic fluids obtained in this work to generate heat under the AMF exposition and the lack of side effects make them a potential means for magnetic hyperthermia. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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