| Autor: |
van Kempen, Léon C. L., Redpath, Margaret, Elchebly, Mounib, Klein, Kathleen Oros, Papadakis, Andreas I., Wilmott, James S., Scolyer, Richard A., Edqvist, Per-Henrik, Pontén, Fredrik, Schadendorf, Dirk, van Rijk, Anke F., Michiels, Stefan, Dumay, Anne, Helbling-Leclerc, Anne, Dessen, Philippe, Wouters, Jasper, Stass, Marguerite, Greenwood, Celia M. T., Ghanem, Ghanem E., van den Oord, Joost |
| Předmět: |
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| Zdroj: |
Science Translational Medicine; 12/14/2016, Vol. 8 Issue 369, p1-13, 13p, 5 Graphs |
| Abstrakt: |
The article discusses sex differences in melanoma prognosis, focusing on the X chromosome expression of the gonosomal protein phosphatase 2 regulatory subunit B beta (PPP2R3B) gene in tumor growth inhibition and cell cycle interference. It is noted that PPP2R3B expression is lower at the pseudoautosomal region (PAR) of the Y chromosome, leading to poorer metastasis-free survival in males. Topics include the impact of the PPP2R3B protein PR70 on DNA replication and cell division cycle in melanoma |
| Databáze: |
Complementary Index |
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