| Autor: |
Kol Jia Yong, Basseres, Daniela S., Welner, Robert S., Wen Cai Zhang, Henry Yang, Benedict Yan, Alberich-Jorda, Meritxell, Junyan Zhang, de Figueiredo-Pontes, Lorena Lobo, Battelli, Chiara, Hetherington, Christopher J., Min Ye, Hong Zhang, Maroni, Giorgia, O’Brien, Karen, Magli, Maria Cristina, Borczuk, Alain C., Varticovski, Lyuba, Kocher, Olivier, Pu Zhang |
| Předmět: |
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| Zdroj: |
Science Translational Medicine; 8/3/2016, Vol. 8 Issue 350, p1-10, 10p, 1 Chart, 5 Graphs |
| Abstrakt: |
The article presents a study which showed that more than 80% of the C/EBα-negative/low adenocarcinoma patients are positive for the expression of the oncogenic protein BMI1 and that this expression pattern has prognostic value. Topics discussed include results showing that a subset of C/EBPα-negative/low and BMI1-positive human adenocarcinomas is amenable to BMI1 pharmacological inhibition and BMI1 is required for lung tumor initiation and maintenance. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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