| Autor: |
Taishi, P., De, A., Alt, J., Gardi, J., Obal Jr., F., Krueger, J. M. |
| Předmět: |
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| Zdroj: |
Journal of Neuroendocrinology; Feb2004, Vol. 16 Issue 2, p113-118, 6p |
| Abstrakt: |
Changes in growth hormone-releasing hormone (GHRH), GHRH-receptor (R), somatostatin and interleukin (IL)-1β mRNA levels were determined in fetal rat hypothalamic cultures after administration of IL-1β (1, 10, 100 ng/ml, 2 h incubation), and in adult rat hypothalamus 5 h after intracerebroventricular injection of IL-1β (2.5 and 25 ng). IL-1β stimulated GHRH-R mRNA expression both in vitro (10 and 100 ng/ml) and in vivo (2.5 and 25 ng). Somatostatin mRNA was significantly stimulated and GHRH mRNA slightly reduced in vitro, while these mRNA species were not altered in vivo in response to IL-1β. IL-1β stimulated its own expression both in vitro (10 and 100 ng/ml) and in vivo (25 ng). IL-1β-induced mRNA responses occurred 2 h after treatment in vitro (incubation times, 30 min to 6 h). IL-1β also elicited slight GHRH releases in vitro. Up-regulation of hypothalamic GHRH-R by IL-1β may explain previous findings suggesting that IL-1β stimulates GHRH activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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