Serum interleukin-17 in Egyptian children with systemic lupus erythematosus: is it related to pulmonary affection?

Autor: Hammad, A., Osman, E., Mosaad, Y., Wahba, M.
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Zdroj: Lupus; Apr2017, Vol. 26 Issue 4, p388-395, 8p, 1 Diagram, 4 Charts, 3 Graphs
Abstrakt: Objective Pulmonary involvement in paediatric systemic lupus erythematosus (pSLE) is not an uncommon finding; however, subclinical affection occurs more frequently. Many studies have reported that cytokine dysregulation as interleukin-17 (IL-17) over-expression plays a key role in the pathogenesis of systemic lupus erythematosus (SLE). We aim to assess serum levels of IL-17 A and their association with pulmonary involvement in children with SLE. Methods Serum IL-17A levels – determined by solid phase sandwich ELISA – were assessed in forty-two pSLE patients and compared to 45 age-matched healthy controls. All patients were subjected to pulmonary function tests to detect subclinical pulmonary affection. High-resolution CT (HRCT) chest scan was carried out in patients with abnormal pulmonary function tests (PFTs) and those with chronic respiratory symptoms. Results Abnormal PFTs were found in 73% of patients; of them, only 25% had abnormal findings in HRCT chest. Serum levels of IL-17 A were significantly elevated in pSLE patients as compared to healthy controls (p < 0.001). The serum levels of IL-17 A had a highly significant positive correlation with SLEDAI (r = 0.811 and p < 0.001) Strong negative correlation was found between serum levels of IL-17A with both FEV1 and FVC (p < 0.05). Conclusions Serum IL-17A is elevated in pSLE patients, which correlates with disease activity. IL-17 seems to have a possible role in the pathogenesis of subclinical lung affection. Abnormal PFTS may be found in pSLE patients even with normal radiology. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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