| Abstrakt: |
Purpose: The clinical differentiation between athlete's heart and mild forms of non-obstructive hypertrophic cardiomyopathy (HCM) is crucial. We hypothesized that differences do exist between the myocardial metabolism of patients with non-obstructive HCM and competitive athletes (CAs). Our aim was to evaluate myocardial metabolism with P-MRS and H-MRS in HCM patients and CAs. Materials and methods: After Ethics Committee approval, 15 CAs and 7 HCM patients were prospectively enrolled. They underwent a 1.5-T cardiac MR including electrocardiographically triggered cine images, single-voxel H-MRS and multivoxel P-MRS. H-MRS was performed after imaging using standard coil with the patient in the supine position; thereafter, P-MRS was performed using a dedicated coil, in the prone position. Data were reported as median and interquartile range. Mann-Whitney U test was used. Results: In CAs, left ventricular mass index was 72 (66-83) g/m, septal thickness 10 (10-11) mm, end diastolic volume index 95 (85-102) ml/m, end systolic volume index 30 (28-32) ml/m and ejection fraction 68% (65-69%); in HCM patients, 81 (76-111) g/m ( P = 0.052), 18 (15-21) mm ( P = 0.003), 73 (58-76) ml/m ( P = 0.029), 20 (16-34) ml/m ( P = 0.274) and 68% (55-73%) ( P = 1.000), respectively. At H-MRS, total lipids were 35 (0-183) arbitrary units (au) for CA and 763 (155-1994) au for HCM patients ( P = 0.046). At P-MRS, PCr/γATP was 5 (4-6) au for CA and 4 (2-5) au for HCM patients ( P = 0.230). Examination time was 20 min for imaging only, 5 min for H-MRS and 15 min for P-MRS. Conclusions: We observed a significant increase of myocardial lipids, but a preserved PCr/γATP ratio in the metabolism of HCM patients compared with competitive CAs. [ABSTRACT FROM AUTHOR] |
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