| Autor: |
Hartsfield, J. K., Jr., Sutcliffe, M. J., Everett, E. T., Hassett, C., Omiecinski, C. J., Saari, J. A. |
| Předmět: |
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| Zdroj: |
Cytogenetics & Cell Genetics; Oct98, Vol. 83 Issue 1/2, p44-45, 2p |
| Abstrakt: |
The article reports on the assignment of microsomal epoxide hydrolase (EPHXI) to human chromosome 1q42.1 by in situ hybridization. Microsomal epoxide hydrolase is an endoplasmic reticulum hound enzyme involved in xenohiotic metabolism. A 40% decrease in microsomal epoxide hydrolase activity in vitro associated with an exon 3 T to C mutation that changes the 113 tyrosine residue to histidine was reported. The presence of this polymorphism has been implicated as a factor in carcinogenesis and emphysema. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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