| Autor: |
Ferguson, Berrylin J., Anon, Jack, Poole, Michael D., Hendrick, Kim, Gilson, Martyn, Seltzer, Elyse G. |
| Zdroj: |
Otolaryngology-Head & Neck Surgery; Jul2002, Vol. 127 Issue 1, p1, 6p |
| Abstrakt: |
Objective: The primary objective of this study was to demonstrate the clinical and radiologic efficacy of 5 days compared with 7 days of gemifloxacin therapy in the treatment of acute bacterial rhinosinusitis (ABRS). Study Design: In this prospective, double-blind, multicenter, parallel-group study, adult patients presenting with ABRS were randomized to receive gemifloxacin 320 mg once daily for either 5 days (n = 218) or 7 days (n = 203). Results: For the primary efficacy end point, clinical response to therapy at follow-up, 5 days of therapy with gemifloxacin was as effective as 7 days of therapy (per-protocol population; treatment difference 0.44%; 95% confidence interval [CI], −6.54 to 7.41). Five and 7 days of treatment with gemifloxacin were well tolerated. Conclusion and Significance: The clinical efficacy of gemifloxacin 320 mg daily for 5 days is at least as good as the efficacy of gemifloxacin 320 mg daily for 7 days in the treatment of ABRS. (Otolaryngol Head Neck Surg 2002;127:1-6.) [Copyright &y& Elsevier] |
| Databáze: |
Complementary Index |
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