| Autor: |
Hensel, Manfred, Buss, Eike C., Tiemann, Markus, Parwaresch, Reza, Libicher, Martin, Fruehauf, Stefan, Ho, Anthony D. |
| Předmět: |
|
| Zdroj: |
European Journal of Haematology; Mar2004, Vol. 72 Issue 3, p217-221, 5p |
| Abstrakt: |
Hensel M, Buss EC, Tiemann M, Parwaresch R, Libicher M, Fruehauf S, Ho AD. Secondary follicular lymphoma of the bone, transformed into large cell lymphoma, in a patient with chronic lymphocytic leukaemia: an uncommon manifestation of Richter's syndrome. Eur J Haematol 2004: 72: 217–221. © Blackwell Munksgaard 2004. Patients with chronic lymphocytic leukemia (CLL) are at a significantly increased risk of developing a second malignant neoplasm in the course of their disease. The occurrence of large cell lymphoma [Richter's syndrome (RS)] has been described in approximately 3–5% of CLL patients. Other types of secondary lymphoid malignancies are extremely rare. Here we describe a patient, heavily pretreated, with long history of CLL who developed a secondary follicular lymphoma, transformed into a diffuse large cell lymphoma (LCL), with isolated manifestation in the bone, a very rare manifestation of RS. CLL and LCL cells were of distinct clonal origin, as documented by DNA sequencing of the CDR3 regions. Twelve months after the completion of chemo- and local radiotherapy, the patient is still in remission. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
