| Autor: |
Hosokawa, Mio, Morizane, Yuki, Hirano, Masayuki, Kimura, Shuhei, Kumase, Fumiaki, Shiode, Yusuke, Doi, Shinichiro, Toshima, Shinji, Hosogi, Mika, Fujiwara, Atsushi, Mitsuhashi, Toshiharu, Shiraga, Fumio |
| Předmět: |
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| Zdroj: |
Japanese Journal of Ophthalmology; Mar2017, Vol. 61 Issue 2, p150-158, 9p |
| Abstrakt: |
Purpose: To evaluate the 1-year treatment outcomes of intravitreal aflibercept injections (IVA) using a treat-and-extend regimen for polypoidal choroidal vasculopathy (PCV). Methods: Thirty-seven eyes with treatment-naive PCV treated with IVA using a treat-and-extend regimen for 1 year were reviewed retrospectively. The main outcome measures were changes in the best-corrected visual acuity (BCVA) and central retinal thickness (CRT), and the treatment interval at 1 year. The predictive factors for patients who could not continue to extend the treatment interval because of poor response to IVA or recurrence were analyzed. Results: The mean logarithm of the minimum angle of resolution BCVA improved from 0.37 at baseline to 0.21 at 1 year ( P < 0.001). The mean CRT decreased from 342.3 μm at baseline to 196.6 μm at 1 year ( P < 0.001). The mean treatment interval was 9.7 weeks at 1 year (4 weeks in 11 eyes [29.7%], 6 weeks in 1 eye [2.7%], 8 weeks in 2 eyes [5.4%], 10 weeks in 1 eye [2.7%], and 12 weeks in 22 eyes [59.5%]). A larger number of polypoidal lesions at baseline was predictive for patients who could not continue to extend the treatment interval. Conclusions: IVA using a treat-and-extend regimen is effective for improving BCVA and CRT in eyes with PCV. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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