| Autor: |
Vara-Messler, Marianela, Pasqualini, Maria, Comba, Andrea, Silva, Renata, Buccellati, Carola, Trenti, Annalisa, Trevisi, Lucia, Eynard, Aldo, Sala, Angelo, Bolego, Chiara, Valentich, Mirta |
| Předmět: |
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| Zdroj: |
European Journal of Nutrition; Mar2017, Vol. 56 Issue 2, p509-519, 11p |
| Abstrakt: |
Objective: The aim of this study was to determine whether α-linolenic acid (ALA ω-3 fatty acid) enriched diet affects growth parameters when applied to a syngeneic model of mammary carcinoma. Materials and methods: BALB/c mice were divided and fed with: 1) a chia oil diet, rich in ALA or 2) a corn oil diet, rich in linoleic acid (LA ω-6 fatty acid). Mice were subcutaneously inoculated with a tumor cell line LM3, derived from a murine mammary adenocarcinoma. Results: After 35 days, tumor incidence, weight, volume and metastasis number were lower in the ALA-fed mice, while tumor latency time was higher, and the release of pro-tumor metabolites derived from ω-6 fatty acids decreased in the tumor. Compared to the control group, a lower number of mitosis, a higher number of apoptotic bodies and higher T-lymphocyte infiltration were consistently observed in the ALA group. An ALA-rich diet decreased the estrogen receptor (ER) α expression, a recognized breast cancer promotor while showing an opposite effect on ERβ in tumor lysates. Conclusion: These data support the anticancer effect of an ALA-enriched diet, which might be used as a dietary strategy in breast cancer prevention. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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