| Autor: |
Mardas, Nikos, Busetti, Juliano, Figueiredo, José Antonio Poli, Mezzomo, Luis André, Scarparo, Roberta Kochenborger, Donos, Nikolaos |
| Předmět: |
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| Zdroj: |
Clinical Oral Implants Research; Mar2017, Vol. 28 Issue 3, p362-371, 10p, 7 Color Photographs, 4 Charts |
| Abstrakt: |
Objectives To evaluate new bone formation in calvarial critical size defects ( CSD) under dense polytetrafluoroethylene (d- PTFE), microporous membranes for guided bone regeneration ( GBR) in healthy, osteoporotic and osteoporotic treated with zoledronic acid ( ZA) rats. Methods Forty-eight, female, 6-month old Wistar rats were included in the study. Osteoporosis was induced by ovariectomy ( OVX) and calcium-deficient diet in 32 rats. Sixteen OVX rats were treated with a single dose of Zolendronic Acid ( ZA) ( OZ), while 16 OVX rats received no treatment (O). The remaining 16 rats were sham-operated and used as healthy controls (C). At 6 weeks following osteoporosis induction, two 5 mm CSD were created in the parietal bones and one of them was treated with a double d- PTFE membrane. The healing periods were 30 and 60 days. New bone formation ( NB) was assessed by qualitative and quantitative histological analysis. Results After 30 days of healing, NB (mean% (95% CI)) was 78.9% (21), 93.1% (9.3) and 84.2% (26.9) in the membrane treated defects and 18.8% (24.1), 27.1% (7.9) and 31% (38.8) in the untreated defects of group O, OZ and C, respectively. After 60 days of healing, NB was 78.3% (14.4), 95.8% (9) and 90.1% (26.1) in the membrane treated defects and 10.8% (17.4), 51.6% (39.4) and 15.7% (12.1) in the untreated defects of group O, OZ and C, respectively. Hierarchical analysis of variance showed that treatment with ZA ( P = 0.001) and the use of membrane ( P = 0.000) significantly increased new bone formation while presence of osteoporosis may have reduced new bone formation ( P = 0.028). Conclusion d- PTFE membranes for GBR promote bone healing in osteoporotic and healthy rats. Treatment with ZA may improve new bone formation in osteoporotic rats. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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