| Autor: |
Hjortrup, P. B., Haase, N., Wetterslev, J., Lange, T., Bundgaard, H., Rasmussen, B. S., Dey, N., Wilkman, E., Christensen, L., Lodahl, D., Bestle, M., Perner, A. |
| Předmět: |
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| Zdroj: |
Acta Anaesthesiologica Scandinavica; Apr2017, Vol. 61 Issue 4, p390-398, 9p, 3 Charts, 1 Graph |
| Abstrakt: |
Background The haemodynamic consequences of fluid resuscitation in septic shock have not been fully elucidated. Therefore, we assessed circulatory effects in the first 24 h of restriction of resuscitation fluid as compared to standard care in intensive care unit ( ICU) patients with septic shock. Methods This was a post-hoc analysis of the multicentre CLASSIC randomised trial in which patients with septic shock, who had received the initial fluid resuscitation, were randomised to a protocol restricting resuscitation fluid or a standard care protocol in nine ICUs. The highest plasma lactate, highest dose of noradrenaline, and the urinary output were recorded in five time frames in the first 24 h after randomisation. We used multiple linear mixed effects models to compare the two groups. Results We included all 151 randomised patients; the cumulated fluid resuscitation volume in the first 24 h after randomisation was median 500 ml (Interquartile range (IQR) 0-1500) and 1250 ml (500-2500) in the fluid restriction group and standard care group, respectively. The estimated differences in the fluid restriction group vs. the standard care group were 0.1 mM (95% confidence interval −0.7 to 0.9; P = 0.86) for lactate, 0.01 μg/kg/min (−0.02 to 0.05; P = 0.48) for dose of noradrenaline, and −0.1 ml/kg/h (−0.3 to 0.2; P = 0.70) for urinary output during the first 24 h after randomisation. Conclusions We observed no indications of worsening of measures of circulatory efficacy in the first 24 h of restriction of resuscitation fluid as compared with standard care in adults with septic shock who had received initial resuscitation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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