| Autor: |
Razny, Urszula, Fedak, Danuta, Kiec‐Wilk, Beata, Goralska, Joanna, Gruca, Anna, Zdzienicka, Anna, Kiec‐Klimczak, Malgorzata, Solnica, Bogdan, Hubalewska‐Dydejczyk, Alicja, Malczewska‐Malec, Malgorzata, Kiec-Wilk, Beata, Kiec-Klimczak, Malgorzata, Hubalewska-Dydejczyk, Alicja, Malczewska-Malec, Malgorzata |
| Předmět: |
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| Zdroj: |
Diabetes/Metabolism Research & Reviews; Mar2017, Vol. 33 Issue 3, pn/a-N.PAG, 11p |
| Abstrakt: |
Background: Carboxylated osteocalcin (Gla-OC) participates in bone remodeling, whereas the undercarboxylated form (Glu-OC) takes part in energy metabolism. This study was undertaken to compare the blood levels of Glu-OC and Gla-OC in nonobese, healthy obese, and prediabetic volunteers and correlate it with the metabolic markers of insulin resistance and early markers of inflammation.Methods: Nonobese (body mass index [BMI] <30 kg/m2 ; n = 34) and obese subjects (30 Results: Gla-OC in obese patients was significantly lower compared to nonobese ones (11.36 ± 0.39 vs 12.69 ± 0.90 ng/mL, P = .048) and weakly correlated with hsCRP (r = -0.18, P = .042), visfatin concentration (r = -0.19, P = .033), and BMI (r = -0.17, P = .047). Glu-OC was negatively associated with fasting insulin levels (r = -0.18, P = .049) and reduced in prediabetic individuals compared with healthy obese volunteers (3.04 ± 0.28 vs 4.48 ± 0.57, P = .025).Conclusions: Decreased blood concentration of Glu-OC may be a selective early symptom of insulin resistance in obesity, whereas the decreased level of Gla-OC seems to be associated with the appearance of early markers of low grade inflammation accompanying obesity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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