| Autor: |
Khairul, Wan M., Yit-Peng Goh, Daud, Adibah Izzati, Nakisah, M. A. |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2017, Vol. 1817 Issue 1, p1-8, 8p, 2 Color Photographs, 1 Diagram, 1 Chart |
| Abstrakt: |
Alkoxy substituted thiourea derivatives with general formula of A-ArC(O)NHC(S)NHAr-D which A represents the methoxy group and D denotes -OCnH2n+1 have been successfully synthesised and characterized. In turn, all the synthesised molecules were assayed for anti-amoebic activities towards Acanthamoeba sp to examine the cytotoxicity effect at their IC50 and membrane permeability. As predicted, the findings showed that the synthesised molecules owing promising anti-amoebic activity towards Acanthamoeba sp. To support, the Acridine-orange/Propidium iodide (AOPI) staining result under fluorescence microscopy revealed the treated amoeba cells by these alkoxy thiourea derivatives exhibited loss in their membrane permeability. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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