The role of neutrophil myeloperoxidase in the development of inflammation induced by thermal skin burns.

Autor: Mikhalchik, E., Budkevich, L., Piterskaya, Yu., Penkov, L., Astamirova, T., Smolina, N., Vakhrusheva, T., Panasenko, O.
Zdroj: Biochemistry (Biokhimiya). Supplemental Series B, Biomedical Chemistry; Jan2017, Vol. 11 Issue 1, p72-75, 4p
Abstrakt: Luminol-dependent chemiluminescence (CL) of blood neutrophils stimulated with phorbol-12- myristate-13-acetate (PMA) and myeloperoxidase (MPO) activity of neutrophils and plasma have been investigated in children ( n = 16) during the early period (1−7 days) after thermal skin burns exceeding 20% of total body surface. The CL level of stimulated neutrophils was higher in burn patients than in healthy children of the reference group ( p lt; 0.01). Increased neutrophil MPO activity was found in 40% of patients, while increased plasma MPO activity was detected in 57% of patients. The albumin fraction isolated from plasma of burn patients increased the PMA-stimulated CL response of blood from healthy donors. These results suggest that the acute inflammatory response to the thermal burn causes neutrophil activation and MPO release into plasma. MPO-mediated modification of plasma proteins, particularly albumin, may stimulate neutrophil activation and provoke further inflammatory response of the body to the thermal injury. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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