| Autor: |
Komives, Claire F., Sanchez, Elda E., Rathore, Anurag S., White, Brandon, Balderrama, Michael, Suntravat, Montamas, Cifelli, Angela, Joshi, Varsha |
| Předmět: |
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| Zdroj: |
Biotechnology Progress; Jan/Feb2017, Vol. 33 Issue 1, p81-86, 6p |
| Abstrakt: |
An eleven amino acid ribosomal peptide was shown to completely neutralize Western Diamondback Rattlesnake (Crotalus atrox) venom in mice when a lethal dose of the venom was pre-incubated with the peptide prior to intravenous injection. We have expressed the peptide as a concatenated chain of peptides and cleaved them apart from an immobilized metal affinity column using a protease. After ultrafiltration steps, the mixture was shown to partially neutralize rattlesnake venom in mice. Preliminary experiments are described here that suggest a potential life-saving therapy could be developed. To date, no recombinant therapies targeting cytotoxic envenomation have been reported. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 33:81-86, 2017 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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