| Autor: |
Mireille, Kameni Poumeni, Desire, Dzeufiet Djomeni Paul, Claude, Bilanda Danielle, Sandrine, Mengue Ngadena Yolande, Francine, Mballa Marguerite, Chantal, Ngoungoure Madeleine, Carolle, Ouafo Agnes, Theophile, Dimo, Pierre, Kamtchouing |
| Předmět: |
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| Zdroj: |
Journal of Experimental & Integrative Medicine; 2016, Vol. 6 Issue 4, p1-7, 7p |
| Abstrakt: |
Introduction: Hypertension represents one of the major risk factors for the development of erectile dysfunction (ED). Protective effects of Nymphaea lotus Linn. on ED and tissular oxidative stress in the N (ω)-nitro-L-arginine methyl ester (L-NAME) hypertensive male rats were investigated in this study. Materials and Methods: Fifty adult male Wistar rats were randomly classified into five groups; control, L-NAME (10 mg/kg), L-NAME + losartan (10 mg/kg), L-NAME + N. lotus at the dose of 75 mg/kg and 200 mg/kg. L-NAME was administered during 8 weeks, but others treatment started from the 4th week and was administered continuously with L-NAME (10 mg/kg) during 4 additional weeks. Results: L-NAME administration caused marked hit of sexual behavior, specifically failure of penile insertion or difficulty to ejaculate during the test interval. Further L-NAME causes a significant decrease in antioxidant products as reduced gluthatione (GSH) and nitric oxide (NO) in aorta and penile tissues, as compared to control group. N. lotus cotreatment for 4 weeks increased markedly the erectile index and the ejaculation rates contrarily to losartan in comparison to negative control receiving only L-NAME. N. lotus, but not the positive drug losartan, induced a significant increase in the antioxidant enzymes activities and GSH and NO levels, as well as, a significant decrease in malondialdehyde levels compared to L-NAME group. These results suggest N. lotus may provide significant protection against L-NAME-induced tissular oxidative damages by upregulation of antioxidant systems and promotion of the vasodilator factors in chronic NO-deficient rats. These alleviating effects of N. lotus denote a prosexual, antioxidant, and vasodilatatory properties that were more appreciated after histological examination where remodeling of aorta was visibly reduced. Conclusion: N. lotus may be considered as a potentially useful strategy to limit ED and toxicity associated with hypertension. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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