| Autor: |
Verma, Amita, Ahmed, Bahar, Anwar, Firoz, Rahman, Mahfoozur, Patel, Dinesh, Kaithwas, Gaurav, Rani, Ravi, Bhatt, Prakash, Kumar, Vikas |
| Předmět: |
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| Zdroj: |
Inflammopharmacology; Feb2017, Vol. 25 Issue 1, p159-175, 17p |
| Abstrakt: |
A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3- O-β- d-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN) (200 mg/kg) and ferric nitrilotriacetate (Fe-NTA) (9 mg/kg) were used for induction of renal cell carcinoma (RCC) in the rats. The rats were further divided into different groups and were treated with HEG doses for 22 weeks. Anti-cancer effect in RCC by HEG was dose dependent to restrict the macroscopical changes as compared to DEN + Fe-NTA-control animals. Significant alteration in biochemical parameters and dose-dependent alleviation in Phase I and Phase II antioxidant enzymes were responsible for its chemo-protective nature. HEG in dose-dependent manner was significant to alter the elevated levels of pro-inflammatory cytokines and inflammatory mediators during RCC. The histopathological changes were observed in the HEG pre-treated group, which was proof for its safety concern as far as its toxicity is concerned. The isolated compound HEG can impart momentous chemo-protection against experimental RCC by suppressing the cyclooxygenase (COX-2) and prostaglandin E2 (PGE) expression via nuclear factor-kappa B (NF-κB) pathway. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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