Toxic Pediatric Parkinsonism: Report of a Child With Metabolic Studies and Response to Treatment.

Autor: Chutorian, Abe M., Bojko, Aviva, Heier, Linda, Frucht, Steven, Nygaard, Toby, Edelberg, David
Předmět:
Zdroj: Journal of Child Neurology; Nov2003, Vol. 18 Issue 11, p812-815, 4p, 4 Black and White Photographs, 1 Graph
Abstrakt: We successfully treated a child with parkinsonism secondary to cytosine arabinoside with levodopa/carbidopa and attempted to elucidate the pathogenesis of the disorder by sequential analysis of cercbrospinal fluid biogenic amines, sequential magnetic resonance imaging, and fluorodopa positron emission tomography, which revealed both permanent and reversible biochemical and structural alterations. The parkinsonian disorder resolved in 9 months. Metabolic changes and structural abnormalities on imaging studies were chronologically correlated with the clinical course. (J Child Neurol 2003; 18:812-815). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index