Harnessing ester bond chemistry for protein ligation.

Autor: Yosaatmadja, Y., Young, P. G., Harris, P. W. R., Baker, E. N., Squire, C. J., Leung, I. K. H.
Předmět:
Zdroj: Chemical Communications; 1/31/2017, Vol. 53 Issue 9, p1502-1505, 4p
Abstrakt: The hydrolysis potential of ester bonds in covalently cross-linking proteins is captured in our novel protein ligation technology. This new type of “molecular superglue” based on the spontaneously-formed Thr–Gln ester bonds found in cell-surface adhesins, affords a unique mechanism to both rationally assemble and disassemble complex protein nanomaterials. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index